Welcome to the Perissi lab!
Responses to cellular stress, differentiation processes, metabolic changes, hormonal stimulation… they all associate with broad changes in gene expression. Changes that need to be tightly regulated for the correct outcome to be achieved.
We are interested in understanding how the integration of different inputs is translated in fine-tuning of transcriptional regulation via the action of signal transduction pathways, ubiquitin conjugating machineries and chromatin remodeling enzymes.
By understanding how cells modulate hormonal, metabolic and inflammatory gene programs in physiological conditions, we hope to contribute to clarify what happens when the same pathways are disrupted under pathological conditions.