Cloud of words most represented in our abstracts  as of May 2020.

Most Recent Lab Publications

  1. English J, Orofino J, Cederquist CT, Paul I, Li H, Auwerx J, Emili A, Belkina A, Cardamone D, Perissi V. GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity. Molecular Metabolism. 2023 Mar;69:101682.
  2. Cardamone MD, Gao Y, Kwan J, Hayashi V, Sheeran M, Xu J, English J, Orofino J, Emili A, Perissi V. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. Journal of Cell Biology. 2022 Mar 7;221(3):e202101021. 
  3. Chan S., Smith E., Gao Y., Kwan J., Blum B.C., Tilston-Lunel A.M., Turcinovic I., Varelas X., Cardamone M.C., Monti S., E,mili A., Perissi V. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Frontiers Cell and Developmental Biology, 07 January 2021
  4. English J, Son JM, Cardamone MD, Lee C, Perissi V. Decoding the rosetta stone of mitonuclear communication. Pharmacological Research,  Nov;161:105161, 2020
  5. Cardamone M.D., Orofino J., Labadorf A., Perissi V.. Chromatin Immunoprecipitation of Murine Brown Adipose Tissue. J Vis Exp. Nov 21;(141), 2018
  6. Cardamone M.D., Tanasa B*., Cederquist C.T.*, Huang J., Mahdaviani K., Li W., Rosenfeld M.G., Liesa M., Perissi V.  Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Molecular Cell, 69(5):757-772, 2018
  7. Lentucci C., Belkina A.*, Cederquist C.T.*, Chan M., Johnson H.E., Prasad S., Lopacinski A., Nikolajczyk B.S., Monti S., Snyder-Cappione J., Tanasa B., Cardamone M.D., Perissi V.  Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. Journal of Biological Chemistry, 292(7):2754-2772, 2017
  8. Cederquist C.T., Lentucci C., Martinez-Calejman C., Hayashi V., Orofino J., Guertin D., Fried S.K., Lee M.J., Cardamone M.D., Perissi V. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Molecular Metabolism, 6(1):125-137, 2016.
  9. Huang J*, Cardamone M.D.*, Johnson H.E., Neault M., Chan M., Floyd E.Z., Mallette F.A., Perissi V. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. Journal of Biological Chemistry, 290(31):19044-54, 2015
  10. Cardamone M.D., Tanasa B., Chan M., Cederquist C.T., Andricovich J., Rosenfeld M.G., Perissi V. GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPARγ. Cell Reports, 8(1):163-76, 2014
  11. Cardamone M.D., Krones A., Tanasa B., Taylor H., Ricci L., Ohgi K.A., Glass C.K., Rosenfeld M.G. & Perissi V.  A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.  Molecular Cell, 46 (1): 91-104, 2012

Collaborations

  1. Oliveira AG, Oliveira LD, Cruz MV, Guimarães DSPSF, Lima TI, Santos-Fávero BC, Luchessi AD, Pauletti BA, Leme AP, Bajgelman MC, Afonso J, Regitano LCA, Carvalho HF, Carneiro EM, Kobarg J, Perissi V, Auwerx J, Silveira LR. Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. Journal of Biological Chemistry, 2023 Jun;299(6):104702. 
  2. Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V, Seidman CE, Seidman J, Chin MT, Chen C, Emili A. Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling. Int J Mol Sci. 2023 Mar 1;24(5):4724.
  3. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Molecular Cell,  Jan 7;81(1):212, 2021
  4. Jones J.E.C., Rabhi N., Orofino J., Gamini R., Perissi V., Vernochet C., Farmer S.R. The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet. Scientific Reports, Feb 11;10(1):2380, 2020
  5. Lima T.I., Guimarães D.S.P.S.F., Oliveira A.G., Araujo H., Sponton C.H.G., Souza-Pinto N.C., Saito Â., Figueira A.C.M., Palameta S., Bajgelman M.C., Calixto A., Pinto S., Mori M.A., Orofino J., Perissi V., Mottis A., Auwerx J., Silveira L.R. Opposing action of NCoR1 and PGC-1α in mitochondrial redox homeostasis. Free Radic Biol Med. Nov 1;143:203-208, 2019
  6. Vincent A.E., Rosa H.S., Pabis K., Lawless C., Chen C., Grünewald A., Rygiel K.A., Rocha M.C., Reeve A.K., Falkous G., Perissi V., White K., Davey T., Petrof B.J., Sayer A.A., Cooper C., Deehan D., Taylor R.W., Turnbull D.M., Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Annals of Neurology, Aug;84(2):289-301, 2018
  7. Mahdaviani K., Benador I.Y., Su S., Gharakhanian R.A., Stiles L., Trudeau K.M., Cardamone M., Enríquez-Zarralanga V., Ritou E,. Aprahamian T., Oliveira M.F., Corkey B.E., Perissi V., Liesa M., Shirihai O.S. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.  EMBO Reports, 18(7):1123-1138, 2017.

 

Other Relevant Publications

  1. Scafoglio C., Smolka M., Zhou H., Perissi V., Rosenfeld MG. The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation. PLOS One 8 (5): e59986, 2013
  2. Perissi V., Jepsen K., Glass C.K. and Rosenfeld M.G. Deconstructing repression: evolving models of co-repressor action. Nature Reviews Genetics, 11(2): 109-23, 2010
  3. Perissi V., Scafoglio C., Zhang J., Ohgi K.A., Rose D.W., Glass C.K. & Rosenfeld M.G. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints.  Molecular Cell, 29 (6), 755-66, 2008
  4. Perissi V. and Rosenfeld M.G. Controlling nuclear receptors: the circular logic of cofactor cycles.  Nature Reviews Molecular Cell Biology, 6 (7), 542-554, 2005
  5. Perissi V., Aggarwal A., Glass C.K., Rose D.W. & Rosenfeld M.G. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.  Cell, 116(4): 511-26, 2004
  6. Li X., Perissi V., Liu F., Rose D.W., Rosenfeld M.G. Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science, 16(5584):1180-3, 2002
  7. Wen Y.D., Perissi V., Staszewski L.M., Yang W.M., Krones A., Glass C.K., Rosenfeld M.G., Seto E. The histone deacetylase-3 complex contains nuclear receptor corepressors. PNAS, 97(13), 7202-7207, 2000
  8. Perissi V., Menini N., Cottone E., Capello D., Sacco M., Montaldo F., De Bortoli M. AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen. Oncogene, 19 (2), 280-288, 2000
  9. Perissi V., Staszewski L.M., McInerney E.M., Kurokawa R., Krones A., Rose D.W., Lambert M.H., Milburn M.V., Glass C.K. & Rosenfeld M.G.  Molecular determinants of nuclear receptor-corepressor interaction.  Genes&Development, 13 (24), 3198-3208, 1999
  10. Perissi V., Dasen J.S., Kurokawa R., Wang Z., Korzus E., Rose D.W., Glass C.K., Rosenfeld M.G. Factor-specific modulation of CREB-binding protein acetyltransferase activity. PNAS, 96(7), 3652-3657, 1999