Our research focuses on gene regulation in immune cells.  Our approach to a systems-level understanding of immune cell responses is through integrative biophysical and genomic study of signal-activated and cell-state transcription factors (TFs). Our work combines high-throughput biophysical and functional studies with genomics datasets to examine how TFs coordinate gene regulation in response to immunological signals. It is our vision that biophysical understanding of TF function combined with genome-scale data will provide generalizable models needed to understand immune signaling in healthy and disease states..

Contact Information

Trevor Siggers (PI): tsiggers@bu.edu

Regular Mail:
Department of Biology
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Boston, MA, 02215

LSEB Room 306
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LSEB Room 324
24 Cummington Mall
Boston, MA, 02215